Home Home Depot - Seguin Hours Monday - Saturday 6:00 a.m. to 10:00 p.m.; Sunday 8:00 a.m. to 8:00 p.m. Amenities Amenities Accessible Home Depot - Seguin201 I-10 Seguin, Texas 78155DetailsOpen in Google Maps Save 201 I-10 Seguin, Texas 78155 Website
